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, Kensaku Nishihira Department of Cardiology, Miyazaki Medical Association Hospital , 1173 Arita, Miyazaki 880-2102 , Japan Corresponding author. Tel: +81 985 77 9101, Fax: +81 985 77 9121, Email: nishihira@med.miyazaki-u.ac.jp Search for other works by this author on: Oxford Academic Yuya Asano Department of Cardiology, Miyazaki Medical Association Hospital , 1173 Arita, Miyazaki 880-2102 , Japan Search for other works by this author on: Oxford Academic Yoshisato Shibata Department of Cardiology, Miyazaki Medical Association Hospital , 1173 Arita, Miyazaki 880-2102 , Japan Search for other works by this author on: Oxford Academic
European Heart Journal, Volume 45, Issue 17, 1 May 2024, Page 1576, https://doi.org/10.1093/eurheartj/ehae073
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Kensaku Nishihira, Yuya Asano, Yoshisato Shibata, Efficacy of pacl*taxel-coated balloon angioplasty combined with intensive lipid-lowering therapy for ST-segment elevation myocardial infarction: insights from near-infrared spectroscopy, European Heart Journal, Volume 45, Issue 17, 1 May 2024, Page 1576, https://doi.org/10.1093/eurheartj/ehae073
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A 43-year-old premenopausal woman with dyslipidaemia was hospitalized due to ST-segment elevation myocardial infarction (STEMI). Coronary angiography identified total occlusion of the right coronary artery (Panel A1; Supplementary data online, Video S1). Near-infrared spectroscopy (NIRS) and intravascular ultrasound demonstrated ultrasound attenuation and extensive yellow signals with maximum lipid core burden index (max-LCBI) of 874 in a 4 mm segment (Panels A2 and A3), indicating the presence of a large amount of lipid-rich material. Given her young age and premenopausal status, we opted for a stentless strategy with pacl*taxel-coated balloon (PCB; 3.0 mm × 20 mm) angioplasty. The lesion was successfully dilated, and sufficient coronary blood flow was achieved, but significant yellow signals remained on NIRS (max-LCBI, 606; Panels B1–B3). After PCB angioplasty, she received intensive lipid-lowering therapy with rosuvastatin (10 mg/day) and ezetimibe (10 mg/day) plus dual antiplatelet therapy with aspirin (100 mg/day) and clopidogrel (75 mg/day). Only aspirin was discontinued after 3 months. After 1 year of intensive lipid-lowering therapy, low-density lipoprotein cholesterol levels decreased from 137 to 52 mg/dL. Follow-up coronary angiography showed no restenosis (Panel C1; Supplementary data online, Video S2). Near-infrared spectroscopy demonstrated a marked reduction in yellow signals (max-LCBI, 244; Panels C2 and C3), suggesting that the residual lipid-rich plaque had stabilized.
Topic:
- pacl*taxel
- st segment elevation myocardial infarction
- balloon angioplasty
- spectroscopy, near-infrared
- lipid-lowering therapy
Issue Section:
CARDIOVASCULAR FLASHLIGHT
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